Well, Buffy and Anne Rice novels may have been what "popularized" the genre in the US, but certainly not where I live. Buffy has been aired here quite successfully, but it wasn't considered to be a serious boost for the vampire genre. (The emphasis lies on "serious".) "Bram Stoker's Dracula", "Interview with the Vampire" or "Blade" did that.
Besides, I don't believe that the screaming teenagers that made at least half of the success of Twilight have been watching Buffy ten years ago or reading Anne Rice novels. What brings me again to the point that Twilight is the movie that's responsible the impression, that the vampire genre is overdone. Because if you look at how successful and how unnervingly omnipresent it is compared to other, much better and more classically themed vampire movies and shows of the last two or three years, you can only come to that conclusion. That's doesn't mean that Twilight isn't also exploiting the popularity of vampire themes in general.
And I know that there's only one Twilight film so far. I said films, because the second one will be released in January 2010, the third in 2011, and both of them will get the same hype and be at least as successful as the first one.
Well, if you're only looking for originality and ingenuity, you won't be happy very often in your "future tv life". I'm satisfied with a show, when it combines at least a couple of the things I want to see like nice storytelling with emotive, intelligent or exciting plots, appealing cinematography, dedicated actors and writers, good humor etc.
Dollhouse for example may have been quite original, but that was about it. The storytelling was too slow at first, with almost no bonding to any of the characters and sometimes lousy build-up. Design, music, cinematography... anything that demanded craftsmanship or production and art awareness was sometimes poorly done. I always hoped, that after the great "Serenity" Joss Whedon had managed to overcome "Buffy - The Vampire Slayer", but seeing Dollhouse I was reminded time and time again of Buffy. Props that obviously looked like plastic, poor paint-jobs, bad make-up, uninspired camerawork, cheap special effects like at some county fair. Most of that improved in the course of the first season, but there is still much to be done. But at least it was original.

Sadly, it took Whedon several episodes to figure out how to properly use the potential of the show.
But if you're into originality, you may check out "United States of Tara", "Flash Forward", "Human Target", "Rubicon", "Caprica", "Bored To Death"... all of them are young or upcoming shows.