There is no up or down due to the fact that space is seemingly infinite and it is this way in all directions. So I suppose unless they find a point of reference in which to base the current direction the Earth and all the other celestial bodies are pointing then there never will be a designation of "up", "down", "left" and "right" because in space it's all the same thing.
If you were floating in space with no major points of reference or you had your eyes closed for whatever reason, you would not be able to tell which direction you were positioned because there is no gravity forcing you to a particular surface which would give you the necessary information to work it out. So space has no direction. Of course during space travel direction needs to be accounted for but this is just to get from one point to another and from our seemingly fixed position here on Earth we can make those sorts of decisions.
